Basic Information
| LncRNA/CircRNA Name | LINC00858 |
| Synonyms | LINC00858 |
| Region | GRCh38_10:84279980-84294659 |
| Ensemble | ENSG00000229404 |
| Refseq | NR_038220 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, RIP, etc. |
| Sample | osteosarcoma tissues, cell lines (MG-63, U2OS, 143 B, Saos-2, hFOB) |
| Expression Pattern | up-regulated |
| Function Description | In further experiments, LINC00858 was identified to sponge miR-139 to form RNA-induced silencing complex (RISC) using luciferase reporter assay and RNA immunoprecipitation (RIP). these data prove that LINC00858/miR-139/CDK14 axis promotes the tumorigenesis of osteosarcoma. |
| Pubmed ID | 29944887 |
| Year | 2018 |
| Title | Long noncoding RNA LINC00858 promotes osteosarcoma through regulating miR-139-CDK14 axis. |
External Links
| Links for LINC00858 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |