Basic Information
| LncRNA/CircRNA Name | LINC00886 |
| Synonyms | NA |
| Region | GRCh38_3:156747346-156817062 |
| Ensemble | ENSG00000240875 |
| Refseq | NR_038387 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal cancer |
| ICD-0-3 | C32 |
| Methods | qRT-PCR |
| Sample | laryngeal cancer cell lines |
| Expression Pattern | down-regulated |
| Function Description | The expression level of LINC00886 in laryngeal cancer cell lines was significantly reversed by 5-Aza-dC. The occurrence of aberrant methylation events in the LINC00886 TSS was more responsible for the down-expression of LINC00886. Over-expression of LINC00886 dramatically mitigated cell proliferation, migration, and invasion in vitro as well as suppressed tumor growth in vivo. LINC00886 may be associated with VEGFA/PI3K/AKT signaling pathways and epithelial-mesenchymal transition (EMT) process. |
| Pubmed ID | 32111441 |
| Year | 2020 |
| Title | Aberrant DNA hypermethylation-silenced LINC00886 gene accelerates malignant progression of laryngeal carcinoma |
External Links
| Links for LINC00886 | GenBank HGNC NONCODE |
| Links for laryngeal cancer | OMIM COSMIC |