Basic Information
| LncRNA/CircRNA Name | LINC00908 |
| Synonyms | NA |
| Region | GRCh38_18:76528655-76610968 |
| Ensemble | ENSG00000263812 |
| Refseq | NR_015417 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | Microarray, RT-qPCR, Western blot analysis, Dual luciferase reporter assay, RIP |
| Sample | paracancerous tissues ,PCa cell lines VCaP, LNCaP, DU-145, PC-3, and human prostate epithelial cell line RWPE-1 |
| Expression Pattern | down-regulated |
| Function Description | Poorly expressed LINC00908 was witnessed in PCa tissues and cells. LINC00908 competitively bound to miR-483-5p to up-regulate the TSPYL5 expression. Overexpression of LINC00908 resulted in reduced PCa cell proliferation, migration and invasion, and promoted apoptosis. |
| Pubmed ID | 31938018 |
| Year | 2020 |
| Title | LINC00908 Negatively Regulates microRNA-483-5p to Increase TSPYL5 Expression and Inhibit the Development of Prostate Cancer |
External Links
| Links for LINC00908 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |