Basic Information
| LncRNA/CircRNA Name | LINC00909 |
| Synonyms | NA |
| Region | GRCh38_18:74591774-74598508 |
| Ensemble | ENSG00000264247 |
| Refseq | NR_024484 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | glioma tissues and adjacent non-cancer tissues ,human glioma cell lines (U87, SHG44, U251, A172, and U-118MG) ,human astroglia cell line (NHA) |
| Expression Pattern | up-regulated |
| Function Description | LINC00909 expression was significantly elevated in glioma tissues and cell lines. High LINC00909 expression was associated with advanced WHO grade, high Karnofsky Performance Score (KPS), and poor prognosis in patients with glioma. LINC00909 depletion inhibited glioma cells proliferation, invasion in vitro and reduced tumor growth in vivo.LINC00909 could act as a ceRNA to interact with miR-194 and thereby up-regulate the expression of MUC1-C, thus promoting the proliferation and invasion of glioma cells. |
| Pubmed ID | 31132669 |
| Year | 2019 |
| Title | LINC00909 Promotes Tumor Progression in Human Glioma Through Regulation of miR-194/MUC1-C Axis |
External Links
| Links for LINC00909 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |