Basic Information
| LncRNA/CircRNA Name | LINC00958 |
| Synonyms | NA |
| Region | GRCh38_11:12961842-12989548 |
| Ensemble | ENSG00000251381 |
| Refseq | NR_038904 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, western blot analysis, Luciferase reporter assay |
| Sample | LUAD cell lines (H157, HCC827, H1975, H1299, and A549), two LUSC cell lines (H520 and H226),TCGA |
| Expression Pattern | up-regulated |
| Function Description | the online databases suggested that LINC00958 was slightly expressed in human normal lung tissues but upregulated in LUSC tissues. Besides, the upregulation of LINC00958 in both lung adenocarcinoma (LUAD) and LUSC cell lines was easily found when compared with the normal BEAS-2B cells. In addition, we elucidated that knockdown of LINC00958 led to impaired proliferation, induced apoptosis, and hampered migration in LUAD cells. Moreover, a typical oncogenic pathway, JNK signaling, was verified to be involved in LINC00958-contributed LUAD development. |
| Pubmed ID | 31855084 |
| Year | 2019 |
| Title | LINC00958 Accelerates Cell Proliferation and Migration in Non-Small Cell Lung Cancer Through JNK/c-JUN Signaling |
External Links
| Links for LINC00958 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |