Basic Information
| LncRNA/CircRNA Name | LINC00958 |
| Synonyms | NA |
| Region | GRCh38_11:12961842-12989548 |
| Ensemble | ENSG00000251381 |
| Refseq | NR_038904 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | RT-qPCR, Luciferase reporter assay, RIP, Western blot analysis |
| Sample | CC tissues,CC cell lines (CaSki, C33A, SiHa, HeLa) as well as the normal cervical epithelial cell line (H8) |
| Expression Pattern | up-regulated |
| Function Description | LINC00958 expression was evidently overexpressed in CC tissues and cells.LINC00958 negatively regulated miR-625-5p expression and was verified to bind with miR-625-5p in CC.LINC00958 facilitates CC cell proliferation and metastasis via the miR-625-5p/LRRC8E axis. |
| Pubmed ID | 31691355 |
| Year | 2020 |
| Title | LINC00958 Facilitates Cervical Cancer Cell Proliferation and Metastasis by Sponging miR-625-5p to Upregulate LRRC8E Expression |
External Links
| Links for LINC00958 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |