Basic Information
| LncRNA/CircRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
| Region | GRCh38_9:21994778-22121097 |
| Ensemble | ENSG00000240498 |
| Refseq | NR_003529 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | gastric cancer tissues, cell lines (MGC803, AGS, and MKN-28) |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that lncRNA-ANRIL was upregulated in human gastric cancer tissues. We demonstrate that TET2 inhibits the proliferation and colony formation of human gastric cancer cells. Overexpression of TET2 induces apoptosis in human gastric cancer cells. The mechanism study shows that TET2 binds to the promoter region of the oncogenic long noncoding RNA (lncRNA-ANRIL) and regulates the expression of ANRIL and its downstream genes (INK4a, INK4b, and ARF). Finally, we demonstrate that ANRIL knockdown blocks the effects of TET2 on gastric cancer cell proliferation and colony formation |
| Pubmed ID | 27027260 |
| Year | 2016 |
| Title | TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells. |
External Links
| Links for ANRIL | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |