Basic Information
| LncRNA/CircRNA Name | LINC00974 |
| Synonyms | NA |
| Region | GRCh38_17:41549606-41554495 |
| Ensemble | ENSG00000226629 |
| Refseq | NR_038442 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, RIP, in vitro knockdown etc. |
| Sample | HCC tissues, blood (plasma) |
| Expression Pattern | up-regulated |
| Function Description | Knockdown of Linc00974 resulted in an inhibition of cell proliferation and invasion with an activation of apoptosis and cell cycle arrest in vitro.The combination of Linc00974 and KRT19 may be novel indices for clinical diagnosis of tumor growth and metastasis in HCC, while Linc00974 may become a potential therapeutic target for the prevention of HCC progression. We also discovered Linc00974F-1 stably expressed in the plasma. |
| Pubmed ID | 25476897 |
| Year | 2014 |
| Title | A novel biomarker Linc00974 interacting with KRT19 promotes proliferation and metastasis in hepatocellular carcinoma. |
External Links
| Links for LINC00974 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |