Basic Information
| LncRNA/CircRNA Name | LINC00976 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR, Western blot |
| Sample | PC tissues, PC cell lines (CFPAC-1, AsPC-1, Mia-Paca2, Panc03.27,BxPC-3, PANC-1) |
| Expression Pattern | up-regulated |
| Function Description | linc00976 expression was overexpressed in PC tissues and cell lines and was positively associated with poorer survival in patients with PC.OTUD7B mediates EGFR and MAPK signaling pathway, suggesting that linc00976/miR-137/OTUD7B/EGFR axis may act as a potential biomarker and therapeutic target for PC. |
| Pubmed ID | 31747939 |
| Year | 2019 |
| Title | Long noncoding RNA 00976 promotes pancreatic cancer progression through OTUD7B by sponging miR-137 involving EGFR/MAPK pathway |
External Links
| Links for LINC00976 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |