Basic Information
| LncRNA/CircRNA Name | LINC00978 |
| Synonyms | MIR4435-2HG, AGD2, AK001796, LINC00978, MIR4435-1HG, MIR4435-2HG |
| Region | GRCh38_2:111036776-111523376 |
| Ensemble | ENSG00000172965 |
| Refseq | NR_015395 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | Microarray, qRT-PCR, Western blot |
| Sample | stomach tissues, human gastric cancer lines (MGC- 803, SGC- 7901, BGC- 823 and HGC- 27) |
| Expression Pattern | up-regulated |
| Function Description | LINC00978 expression level was elevated in GC tumour tissues, serum samples and cell lines. The expression level of LINC00978 was significantly correlated with tumour size (P=0.02), lymphatic metastasis (P=0.009) and TNM stage (P=0.009). LINC00978 knockdown inhibited the proliferation of GC cells by suppressing cell cycle progression and inducing apoptosis. LINC00978 knockdown also inhibited the migration and invasion of GC cells. In addition, LINC00978 knockdown inhibited the activation of TGF-B/SMAD signalling pathway and the process of epithelial-mesenchymal transition (EMT) in GC cells. Moreover, the in vivo tumorigenicity of LINC00978 knockdown GC cells in mice was significantly decreased. |
| Pubmed ID | 29271006 |
| Year | 2017 |
| Title | Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer. |
External Links
| Links for LINC00978 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |