Basic Information
| LncRNA/CircRNA Name | LINC01013 |
| Synonyms | NA |
| Region | GRCh38_6:132131915-132169374 |
| Ensemble | ENSG00000228495 |
| Refseq | NR_038981 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | anaplastic large-cell lymphoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Cell migration and invasion assay etc. |
| Sample | ALCL tumor tissues, cell lines (SR-786, KARPAS-299) |
| Expression Pattern | up-regulated |
| Function Description | LINC01013 was highly expressed in clinical specimens of ALCL and was significantly upregulated in invasive ALCL cell lines. Knockdown of LINC01013 suppressed tumor cell invasion; conversely, its overexpression enhanced tumor cell invasion. LINC01013-induced invasion was mediated by activation of the epithelial-to-mesenchymal transition (EMT)-associated proteins, snail and fibronectin. Specifically, LINC01013 induced snail, resulting in activation of fibronectin and enhanced ALCL cell invasion. |
| Pubmed ID | 28331184 |
| Year | 2017 |
| Title | The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma. |
External Links
| Links for LINC01013 | GenBank HGNC NONCODE |
| Links for anaplastic large-cell lymphoma | OMIM COSMIC |