Basic Information
| LncRNA/CircRNA Name | LINC01021 |
| Synonyms | NA |
| Region | GRCh38_5:27472292-27496401 |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot etc. |
| Sample | cell lines (HCT116, SW48, RKO) |
| Expression Pattern | up-regulated |
| Function Description | LINC01021 is an integral part of the p53-mediated response to DNA damage. Inactivation of LINC01021 and also its ectopic expression did not affect p53 protein expression and transcriptional activity, implying that LINC01021 does not feedback to p53. Furthermore, in CRC patient samples LINC01021 expression positively correlated with a wild-type p53-associated gene expression signature. LINC01021 expression was increased in primary colorectal tumors and displayed a bimodal distribution that was particularly pronounced in the mesenchymal CMS4 consensus molecular subtype of CRCs. CMS4 tumors with low LINC01021 expression were associated with poor patient survival. |
| Pubmed ID | 29262524 |
| Year | 2017 |
| Title | Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity |
External Links
| Links for LINC01021 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |