Basic Information
| LncRNA/CircRNA Name | LINC01082 |
| Synonyms | TCONS_00024492 |
| Region | GRCh38_16:86196181-86199720 |
| Ensemble | ENSG00000269186 |
| Refseq | NR_103859 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, other |
| Sample | colon cancer tissues and cell lines (HCT116, sw480 and sw620) |
| Expression Pattern | down-regulated |
| Function Description | The results revealed that LINC01082 was significantly decreased in tissues and cell lines of colon cancer. Overexpressed LINC01082 significantly suppressed the proliferation ability of colon cancer cells. The migration and invasion of colon cancer cells were also suppressed after LINC01082 overexpression. These findings demonstrated that LINC01082 may act in suppressing the incidence and development of colon cancer via suppressing cell proliferation, migration and invasion, indicating that LINC01082 may act as a new tumor suppressor and may be a promising therapy target for colon cancer. |
| Pubmed ID | 31432387 |
| Year | 2019 |
| Title | Overexpression LINC01082 Suppresses the Proliferation, Migration and Invasion of Colon Cancer |
External Links
| Links for LINC01082 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |