Basic Information
| LncRNA/CircRNA Name | LINC01088 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, western blot, RIP |
| Sample | NSCLC tissues,NSCLC cell lines (A549, HCC827, H358, H1299, H1975, and SPC-A-1) and normal lung cell line (16HBE) |
| Expression Pattern | up-regulated |
| Function Description | linc01088 and EZH2 were highly expressed both in NSCLC tissues and cell lines. Knockdown of linc01088 suppressed the proliferation of NSCLC cells, and prolonged the G1 phase while shortened S and G2-M phases. RIP assay revealed the direct binding relationship between linc01088 and EZH2. Knockdown of either linc01088 or EZH2 induced up-regulation of p21 expression, which subsequently inhibited the tumor growth. |
| Pubmed ID | 31811854 |
| Year | 2020 |
| Title | linc01088 Promotes Cell Proliferation by Scaffolding EZH2 and Repressing p21 in Human Non-Small Cell Lung Cancer |
External Links
| Links for LINC01088 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |