Basic Information
| LncRNA/CircRNA Name | LINC01111 |
| Synonyms | NA |
| Region | GRCh38_8:76406654-76524356 |
| Ensemble | ENSG00000254300 |
| Refseq | NR_105006 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | PC tissues,cell lines (PANC-1, MIA PaCa-2, SW1990, Capan-2, Panc 03.27, BxPC-3, CFPAC-1) |
| Expression Pattern | down-regulated |
| Function Description | Furthermore, we found that high expression levels of LINC01111 upregulated DUSP1 levels by sequestering miR-3924, resulting in the blockage of SAPK phosphorylation and the inactivation of the SAPK/JNK signaling pathway in PC cells and thus inhibiting PC aggressiveness. Overall, these data reveal that LINC01111 is a potential diagnostic biomarker for PC patients, and the newly identified LINC01111/miR-3924/DUSP1 axis can modulate PC initiation and development. |
| Pubmed ID | 31767833 |
| Year | 2019 |
| Title | Long Noncoding RNA LINC01111 Suppresses Pancreatic Cancer Aggressiveness by Regulating DUSP1 Expression via microRNA-3924 |
External Links
| Links for LINC01111 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |