Basic Information
| LncRNA/CircRNA Name | LINC01116 |
| Synonyms | NA |
| Region | GRCh38_2:176629589-176637931 |
| Ensemble | ENSG00000163364 |
| Refseq | NR_040001 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Gefitinib | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot Analyses |
| Sample | non-small cell lung cancer cell line PC9 |
| Expression Pattern | up-regulated |
| Function Description | LINC01116 is upregulated in the gefitinib-resistant NSCLC cells and tissues. Loss- and gain-of-function assays uncovered that LINC01116 downregulation sensitized gefitinib resistance, whereas the overexpression of LINC01116 conferred PC9/R cells to gefitinib resistance. Moreover, LINC01116 silencing increased IFI44 expression.downregulation of LINC01116 increased the sensitivity of PC9/R cells to gefitinib in vivo. |
| Pubmed ID | 31841994 |
| Year | 2020 |
| Title | Long Noncoding RNA LINC01116 Contributes to Gefitinib Resistance in Non-small Cell Lung Cancer Through Regulating IFI44 |
External Links
| Links for LINC01116 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |