Basic Information
| LncRNA/CircRNA Name | LINC01116 |
| Synonyms | NA |
| Region | GRCh38_2:176629589-176637931 |
| Ensemble | ENSG00000163364 |
| Refseq | NR_040001 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot, Dual luciferase reporter assay |
| Sample | osteosarcoma tissues, cell lines (MG-63, U-2OS, Saos-2, hFOB 1.19) |
| Expression Pattern | up-regulated |
| Function Description | LINC01116 and IL6R were up-regulated while miR-520a-3p was down-regulated in OS. LINC01116 and IL6R promoted the viability and migration of OS cells, Lower expression levels of miR-520a-3p significantly correlated with shorter survival of patients. The viability of OS cells was suppressed by si-LINC01116, whereas the apoptosis was promoted by si-LINC01116. |
| Pubmed ID | 30098545 |
| Year | 2018 |
| Title | LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway. |
External Links
| Links for LINC01116 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |