Basic Information
| LncRNA/CircRNA Name | LINC01121 |
| Synonyms | NA |
| Region | GRCh38_2:45164870-45323295 |
| Ensemble | ENSG00000205054 |
| Refseq | NR_033831 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot |
| Sample | pancreatic cancer tissues, cell lines (PANC-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC01121 was highly expressed, while low expressions of GLP1R in pancreatic cancer. The target prediction program and luciferase activity analysis was testament to the notion suggesting that GLP1R was indeed a target of LINC01121. In contrast to the blank and NC groups, the LINC01121 vector group exhibited increased expressions of LINC01121; decreased mRNA and protein levels of GLP1R, Bad, cAMP, and PKA; increased protein levels of CREB, Bcl-2, PCNA, p-PKA and p-CREB; increased cell proliferation, migration and invasion; and decreased cell apoptosis. There was no significant difference detected among the blank, NC, and siRNA-LINC01121 + siRNA-GLP1R groups, except that decreased LINC01121 expression was determined in the siRNA-LINC01121 + siRNA-GLP1R group. Parallel data were observed in the pancreatic cancer cells and PANC-1 cells. |
| Pubmed ID | 29843149 |
| Year | 2018 |
| Title | LINC01121 Inhibits Cell Apoptosis While Facilitating Proliferation, Migration, and Invasion Though Negative Regulation of the Camp/PKA Signaling Pathway via GLP1R |
External Links
| Links for LINC01121 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |