Basic Information
| LncRNA/CircRNA Name | LINC01140 |
| Synonyms | NA |
| Region | GRCh38_1:87129765-87169198 |
| Ensemble | ENSG00000267272 |
| Refseq | NR_026985 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc |
| Sample | cell lines(U87, U251, SHG-44, and U-118MG) |
| Expression Pattern | up-regulated |
| Function Description | The expressions of LINC01140 were promoted in glioma. Silencing LINC01140 could inhibit glioma cell viabilities, migration, and invasion. In our experiments, miR-199a-3p was inhibited in glioma. LINC01140 negatively regulated the expressions of miR-199a-3p in glioma. MiR-199a-3p could target ZHX1 to inhibit its expression in glioma cells. |
| Pubmed ID | 32184618 |
| Year | 2020 |
| Title | LncRNA LINC01140 Inhibits Glioma Cell Migration and Invasion via Modulation of miR-199a-3p/ZHX1 Axis |
External Links
| Links for LINC01140 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |