Basic Information
| LncRNA/CircRNA Name | LINC01186 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, other |
| Sample | PTC tissues and cell lines (TPC-1, K1 and IHH-4) |
| Expression Pattern | up-regulated |
| Function Description | LINC01186 expression was associated with lymph node metastasis of PTC patients. Functionally, LINC01186 overexpression significantly suppressed cell proliferation, cell colony formation and cell invasion ability in TPC-1 and IHH-4 cells. In addition, we demonstrated that LINC01186 overexpression inhibited large tumor suppressor kinase 1 (LATS1)/YY1 associated protein 1 (YAP) signaling by reducing YAP1 expression, while increasing LATS1 expression in TPC-1 and IHH-4 cells. |
| Pubmed ID | 30344719 |
| Year | 2018 |
| Title | The LINC01186 Suppresses Cell Proliferation and Invasion Ability in Papillary Thyroid Carcinoma |
External Links
| Links for LINC01186 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |