Basic Information
| LncRNA/CircRNA Name | LINC01224 |
| Synonyms | NA |
| Region | GRCh38_19:23399233-23416075 |
| Ensemble | ENSG00000269416 |
| Refseq | NR_126448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Western blot analysis, Dual Luciferase Reporter Assay, RIP |
| Sample | HCC tissues,HCC cell lines HepG2, HuH-7, Bel-7402, and SMMC-7721 and the normal cell line L-02 |
| Expression Pattern | up-regulated |
| Function Description | LINC01224 and CHEK1 were upregulated and miR-330-5p was downregulated in HCC cells.LINC01224 could specifically bind to miR-330-5p, and CHEK1 was identified as a target gene of miR-330-5p. When LINC01224 was silenced or miR-330-5p was elevated, the sphere and colony formation abilities and proliferative, migrative, and invasive potentials of HCC cells were diminished, while cell cycle arrest and apoptosis were enhanced.LINC01224 induced HCC progression in vitro and accelerated tumor formation in nude mice by increasing CHEK1 expression. |
| Pubmed ID | 31902747 |
| Year | 2020 |
| Title | Silencing Long Non-coding RNA LINC01224 Inhibits Hepatocellular Carcinoma Progression via MicroRNA-330-5p-Induced Inhibition of CHEK1 |
External Links
| Links for LINC01224 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |