Basic Information
| LncRNA/CircRNA Name | LINC01225 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | GC tissues, GC cell lines SGC-7901, MGC-803, HGC-27, AGS and BGC-823, normal gastric epithelial cell line (GES-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC01225 was up regulated in tumour tissues and plasma of GC. Analysis with clinicopathological information suggested that up regulation of LINC01225 was as sociated with advanced disease and poorer overall survival. Receiver operating char acteristic (ROC) analysis showed that plasma LINC01225 had a moderate accuracy for diagnosis of GC. In addition, knockdown of LINC01225 led to retardation of cell proliferation, invasion and migration, and overexpression of LINC01225 showed the opposite effects. Mechanistic investigations showed that LINC01225 silencing inhib ited epithelial mesenchymal transition (EMT) process and attenuated Wnt/? catenin signalling of GC. Furthermore, ectopic expression of Wnt1 or suppression of GSK 3? abolished the si LINC01225 mediated suppression against EMT, thereby promoting cell proliferation, invasion and migration of GC. |
| Pubmed ID | 31460694 |
| Year | 2019 |
| Title | Long non-coding RNA LINC01225 promotes proliferation, invasion and migration of gastric cancer via Wnt/?-catenin signalling pathway |
External Links
| Links for LINC01225 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |