Basic Information
| LncRNA/CircRNA Name | LINC01288 |
| Synonyms | NA |
| Region | GRCh38_8:34784052-34864798 |
| Ensemble | ENSG00000254344 |
| Refseq | NR_125746 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | normal adjacent tissues and tumor tissues ,cell lines(WI-38, A549, 95D, H838, H358, H1299) |
| Expression Pattern | up-regulated |
| Function Description | LINC01288 is frequently upregulated in NSCLC samples and cell lines. LINC01288 significantly promotes viability, migration, xenograft tumor growth and metastasis in vitro and in vivo.LINC01288 physically interacts with the IL-6 mRNA and increase the stability of IL-6 transcripts.Subsequently, the autocrine induction of IL-6 and enhanced STAT3 activation may facilitate NSCLC progression.Collectively,LINC01288 serves as a crucial mediator of IL-6/STAT3 pathway and created novel interplay between lncRNAs and tumor development. |
| Pubmed ID | 31054777 |
| Year | 2019 |
| Title | A Long Non-Coding RNA LINC01288 Facilitates Non-Small Cell Lung Cancer Progression Through Stabilizing IL-6 mRNA |
External Links
| Links for LINC01288 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |