Basic Information
| LncRNA/CircRNA Name | LINC01354 |
| Synonyms | NA |
| Region | GRCh38_1:234527891-234531779 |
| Ensemble | ENSG00000231768 |
| Refseq | NR_038426 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot |
| Sample | osteosarcoma tissues,cell Lines,blood |
| Expression Pattern | up-regulated |
| Function Description | LINC01354 overexpression promoted OS cells invasion, EMT and integrin b1 expression, while knockdown of LINC01354 inhibited OS cell invasion, epithelialemesenchymal transition (EMT) and integrin b1 expression. In addition, integrin-b1 blockage with MAB13 antibody abrogated the effects of LINC01354 overexpression on promoting OS cells invasion and EMT. In addition, LINC01354 promoted OS cell metastasis in vivo. |
| Pubmed ID | 32111497 |
| Year | 2019 |
| Title | LINC01354 Promotes Osteosarcoma Cell Invasion by Up-regulating Integrin b1 |
External Links
| Links for LINC01354 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |