Basic Information
LncRNA/CircRNA Name | LINC01419 |
Synonyms | NA |
Region | GRCh38_8:83403758-83408900 |
Ensemble | ENSG00000253898 |
Refseq | NR_122034 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | lung adenocarcinoma |
ICD-0-3 | C34 |
Methods | qRT-PCR , Luciferase reporter assay , Western blot , RIP , in vitro knockdown etc. |
Sample | LUAD cell lines (SPC-A1, A549, H446 and H460) and normal pulmonary epithelial cell (BEAS-2B). |
Expression Pattern | up-regulated |
Function Description | LINC01419 level was high in LUAD cells, and LINC01419 knockdown inhibited carcinogenesis via suppressing cell proliferation, migration as well as invasion.miR-519-3p was sequestered and negatively regulated by LINC01419. Subsequently, RCCD1 was identified as a miR-519b-3p target and had inverse relationship with miR-519b-3p. LINC01419 was positively related to RCCD1.miR-519b-3p inhibitor or RCCD1 overexpression could neutralize the effect of LINC01419 silenced in cell proliferation, migration and invasion. |
Pubmed ID | 31582214 |
Year | 2019 |
Title | LINC01419 Promotes Cell Proliferation and Metastasis in Lung Adenocarcinoma via Sponging miR-519b-3p to Up-Regulate RCCD1 |
External Links
Links for LINC01419 | GenBank HGNC NONCODE |
Links for lung adenocarcinoma | OMIM COSMIC |