Basic Information
| LncRNA/CircRNA Name | LINC01433 |
| Synonyms | LOC728228 |
| Region | GRCh38_20:4193065-4195943 |
| Ensemble | ENSG00000230176 |
| Refseq | NR_033917 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP, RNAi, other |
| Sample | HCC tissues and cell lines(Huh-7, HepG2, Hep3B, MHCC97L, SMCC-7721, and LO2) |
| Expression Pattern | up-regulated |
| Function Description | On the contrary, overexpression of LINC01433 promoted HCC cell proliferation, increased cell colony formation, and enhanced cell invasion capacity. Subsequently, we found that miR-1301 was remarkably decreased in HCC cells, and it can serve as a target of LINC01433 according to bioinformatics analysis. In addition, the binding correlation between them was validated by performing RNA pull-down experiments and RIP assay. Moreover, STAT3 was predicted and validated as a target of miR-1301, and it was shown that miR-1301 mimics significantly suppressed STAT3 in HCC cells. Finally, in vivo models were established, and the results demonstrated that silencing of LINC01433 could repress HCC development through modulating miR-1301 and STAT3. |
| Pubmed ID | 30317567 |
| Year | 2019 |
| Title | LINC01433 Promotes Hepatocellular Carcinoma Progression via Modulating the miR-1301/STAT3 Axis |
External Links
| Links for LINC01433 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |