Basic Information
| LncRNA/CircRNA Name | LINC01436 |
| Synonyms | NA |
| Region | GRCh38_21:36005338-36007838 |
| Ensemble | ENSG00000231106 |
| Refseq | NR_110419 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Luciferase assay, RIP, Western blot |
| Sample | Cancer tissue samples,AGS and BGC-823 cell lines |
| Expression Pattern | up-regulated |
| Function Description | LINC01436 was significantly up-regulated in cancerous tissues of GC samples, and its overexpression was correlated with a worse prognosis for the patients. In the GC cell line BGC823 cells, LINC01436 knockdown repressed the proliferation and metastasis of cancer cells; conversely, in GC cell line AGS cells, overexpression of LINC01436 showed the opposite effects. |
| Pubmed ID | 31829474 |
| Year | 2020 |
| Title | LINC01436, Regulating miR-585 and FBXO11, Is an Oncogenic lncRNA in the Progression of Gastric Cancer |
External Links
| Links for LINC01436 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |