Basic Information
| LncRNA/CircRNA Name | LINC01446 |
| Synonyms | NA |
| Region | GRCh38_7:53655509-53811931 |
| Ensemble | ENSG00000205628 |
| Refseq | NR_038371 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, luciferase reporter assay |
| Sample | glioblastoma tissues, cell lines (NHA, A172, U87, U251, T98G) |
| Expression Pattern | up-regulated |
| Function Description | Our study revealed a novel lncRNA LINC01446 whose expression was elevated in GBM tissues. high expression of LINC01446 indicated a poor prognosis in GBM patients. LINC01446 knockdown dramatically inhibited GBM cell proliferation, arrested cell-cycle progression and attenuated invasion in vitro. bioinformatics analysis showed that LINC01446 acted as a sponge for miR-489-3p which targeted TPT1. |
| Pubmed ID | 30029885 |
| Year | 2018 |
| Title | LncRNA LINC01446 Promotes Glioblastoma Progression by Modulating miR-489-3p/TPT1 Axis. |
External Links
| Links for LINC01446 | GenBank HGNC NONCODE |
| Links for glioblastoma | OMIM COSMIC |