Basic Information
| LncRNA/CircRNA Name | ABHD11-AS1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000225969 |
| Refseq | NR_026690 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc. |
| Sample | CRC tissues, CRC cell lines (HCT-116, HCT-8, SW-480, SW-620, and HT-29) and the human normal colorectal epithelial cell (FHC) |
| Expression Pattern | up-regulated |
| Function Description | ABHD11 AS1 was highly expressed in CRC tissues and cell lines. High ABHD11 AS1 expression was correlated with poor overall survival of patients with CRC. ABHD11 AS1 knockdown reduced CRC cell proliferation, in vitro invasion, and in vivo tumor growth. Investigation of the underlying mechanism showed that ABHD11 AS1 could act as a molecular sponge of miR 1254, and WNT11 was a downstream target of miR 1254 in CRC. Moreover, there was a negative association between ABHD11 AS1 expression (or WNT11) and miR 1254 in CRC tissues. The rescue assays showed that WNT11 overexpression partially rescued the effects of ABHD11 AS1 inhibition on CRC progression. |
| Pubmed ID | 30537177 |
| Year | 2018 |
| Title | Long noncoding RNA ABHD11 AS1 promote cells proliferation and invasion of colorectal cancer via regulating the miR 1254 WNT11 pathway |
External Links
| Links for ABHD11-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |