Basic Information
| LncRNA/CircRNA Name | LINC01503 |
| Synonyms | lnc-PPP2R4-5 |
| Region | GRCh38_9:129332300-129359538 |
| Ensemble | ENSG00000233901 |
| Refseq | NR_120685 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | RNA-seq, Microarray, qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown, RNAi, RIP |
| Sample | non-tumor esophageal tissues, cell lines (OE33 and FLO-1, TE7, TE5 and KYSE510, KYSE30 ) |
| Expression Pattern | up-regulated |
| Function Description | High levels in SCCs correlated with shorter survival times of patients. The transcription factor TP63 bound to the super enhancer at the LINC01503 locus and activated its transcription. Expression of LINC01503 in ESCC cell lines increased their proliferation, colony formation, migration, and invasion. Knockdown of LINC01503 in SCC cells reduced their proliferation, colony formation, migration, and invasion, and the growth of xenograft tumors in nude mice. Expression of LINC01503 in ESCC cell lines reduced ERK2 dephosphorylation by DUSP6, leading to activation of ERK signaling via MAPK. |
| Pubmed ID | 29454790 |
| Year | 2018 |
| Title | Increased Expression of the Long Non-Coding RNA LINC01503, Regulated by TP63, in Squamous Cell Carcinoma and Effects on Oncogenic Activities of Cancer Cell Lines. |
External Links
| Links for LINC01503 | GenBank HGNC NONCODE |
| Links for squamous cell carcinoma | OMIM COSMIC |