Basic Information
| LncRNA/CircRNA Name | LINC01510 |
| Synonyms | NA |
| Region | GRCh38_7:116570960-116614820 |
| Ensemble | ENSG00000231210 |
| Refseq | NR_120506 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | PTC tumor tissues and adjacent normal tissues ,cell lines(Nthy-ori3-1 (control cells) and PTC ) |
| Expression Pattern | up-regulated |
| Function Description | LINC01510 was highly expressed in both PTC tissues and cell lines.Knockdown of LINC01510 suppressed the proliferation, migration and invasion of SW1736 and TPC-1 cells.Moreover, down-regulation of LINC01510 resulted in accelerated apoptosis by promoting the expression of Caspase3/9.LINC01510 acted as an endogenous sponge by directly binding miR-335, resulting in the suppression of miR-335 expressions.SHH was a target of miR-335 and miR-335 over-expression distinctly reduced SHH expression in PTC cells.LINC01510 acted as a sponge for miR-335, reducing its ability to promote SHH expression.Knockdown of LINC01510 inhibited the expression of SHH and GLI1, suggesting that Hedgehog pathway was suppressed. |
| Pubmed ID | 31590919 |
| Year | 2019 |
| Title | SOX2-induced Upregulation of lncRNA LINC01510 Promotes Papillary Thyroid Carcinoma Progression by Modulating miR-335/SHH and Activating Hedgehog Pathway |
External Links
| Links for LINC01510 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |