Basic Information
| LncRNA/CircRNA Name | LINC01510 |
| Synonyms | NA |
| Region | GRCh38_7:116570960-116614820 |
| Ensemble | ENSG00000231210 |
| Refseq | NR_120506 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP, other |
| Sample | NSCLC tissues and cell lines (A549, H460, SPC-A1 and H23) |
| Expression Pattern | up-regulated |
| Function Description | LINC01510 over-expression promoted NSCLC cell proliferation, cell cycle progression, migration and invasion, but shRNA-mediated LINC01510 depletion inhibited NSCLC cell proliferation, cell cycle progression, migration and invasion. Notably, LINC01510 ablation suppressed tumorigenicity of NSCLC cells in a murine xenograft model. Furthermore, mechanistic studies revealed that LINC01510 exerted its oncogenic functions in NSCLC through miR-339-5p-mediated regulation of CDK14. |
| Pubmed ID | 30399588 |
| Year | 2019 |
| Title | Increased expression of LINC01510 predicts poor prognosis and promotes malignant progression in human non-small cell lung cancer. |
External Links
| Links for LINC01510 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |