Basic Information
| LncRNA/CircRNA Name | LINC01510 |
| Synonyms | NA |
| Region | GRCh38_7:116570960-116614820 |
| Ensemble | ENSG00000231210 |
| Refseq | NR_120506 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, other |
| Sample | RCC tissues and cell lines (786-O, Caki-2) |
| Expression Pattern | down-regulated |
| Function Description | Moreover, the down-regulated LINC01510 was further confirmed in our fresh tissues and cell lines. Biological functions assays shown that Ectopic expression of LINC01510 not only inhibits RCC cell proliferation both in vitro and in vivo, but also impairs cell invasion ability. Moreover, we found overexpression of LINC01510 inhibits the expression of CCND1 and CCNE1, as well as MMPs (MMP2, MMP7 and MMP9), and thus affecting RCC cell cycle and invasion. Meanwhile, Western blot assays revealed that the expression of ?-catenin is regulated by LINC01510; overexpression of ?-catenin could partly rescue the cell viability and invasion ability caused by ectopic expression of LINC01510. |
| Pubmed ID | 30224058 |
| Year | 2018 |
| Title | LINC01510 Suppresses Cell Proliferation and Invasion by Inhibiting Wnt/?-catenin Signaling in Renal Cell Carcinoma |
External Links
| Links for LINC01510 | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |