Basic Information
| LncRNA/CircRNA Name | AOC4P |
| Synonyms | AOC4P, AOC4, UPAT |
| Region | GRCh38_17:42865922-42874369 |
| Ensemble | ENSG00000260105 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot etc |
| Sample | cell lines (NCI-H460, PC-9, SPC-A1, NCI-H1650, A549) |
| Expression Pattern | down-regulated |
| Function Description | AOC4P was lowly expressed in NSCLC samples and cells. Overexpression of AOC4P inhibited viability, the expression of MMP-2 and MMP-9, and invasion of NSCLC cells. Apoptosis and caspase-3/7 activity were suppressed in response to AOC4P overexpression in NSCLC cells. AOC4P overexpression suppressed tumor growth in a xenograft mouse model. |
| Pubmed ID | 32325081 |
| Year | 2020 |
| Title | AOC4P suppresses viability and invasion and induces apoptosis in NSCLC cells by inhibiting the Wnt/?-catenin pathway. |
External Links
| Links for AOC4P | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |