Basic Information
| LncRNA/CircRNA Name | LINC01638 |
| Synonyms | NA |
| Region | GRCh38_22:27221349-27224727 |
| Ensemble | ENSG00000233521 |
| Refseq | NM_001350812 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 |
| Methods | RT-qPCR, Western blot analysis |
| Sample | Blood,Tumor tissues,PDAC cell line PL45 and normal pancreas duct cell line hTERT-HPNE |
| Expression Pattern | up-regulated |
| Function Description | LINC01638 was significantly upregulated in tumor tissues.LINC01638 overexpression increased TGF-?1 expression, while silencing of LINC01638 using short hairpin RNA (shRNA) led to reduced TGF-?1 expression in a PDAC cell line. LINC01638 overexpression promoted, while shRNA silencing inhibited, migration and invasion of cell of a PDAC cell line. |
| Pubmed ID | 31702018 |
| Year | 2019 |
| Title | Downregulation of LINC01638 lncRNA Inhibits Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells by Reducing TGF-? Signaling |
External Links
| Links for LINC01638 | GenBank HGNC NONCODE |
| Links for pancreatic ductal adenocarcinoma | OMIM COSMIC |