Basic Information
| LncRNA/CircRNA Name | LINC01857 |
| Synonyms | NA |
| Region | GRCh38_2:207662375-207667024 |
| Ensemble | ENSG00000224137 |
| Refseq | NR_135567 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RIP, etc. |
| Sample | breast cancer tissue, Human breast epithelial cell line (MCF10A) and breast cancer cell lines (MCF7, BT-20, T47D, and SKBR3) |
| Expression Pattern | up-regulated |
| Function Description | LINC01857 was highly expressed in breast cancer tissues and cells (p < 0.05). High LINC01857 expression predicted poor prognosis in breast cancer patients. Functionally, LINC01857 silencing impaired proliferation and enhanced apoptosis of breast cancer cells (p < 0.05). Decreased LINC01857 inhibited breast cancer cells migration and invasion ability (p < 0.05). In terms of mechanism, LINC01857 promoted H3K27Ac deposition on CREB1 promoter and initiated its transcription by recruiting CREBBP. Overexpression of CREB1 reversed the biological behavior of breast cancer cells induced by LINC01857 silencing (p < 0.05). |
| Pubmed ID | 30628071 |
| Year | 2019 |
| Title | LINC01857 as an oncogene regulates CREB1 activation by interacting with CREBBP in breast cancer. |
External Links
| Links for LINC01857 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |