Basic Information
| LncRNA/CircRNA Name | LINC02476 |
| Synonyms | NA |
| Region | GRCh38_7:119704556-119907375 |
| Ensemble | ENSG00000225546 |
| Refseq | NR_131962 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | HCC tissues, cell lines (Bel7402, Hep3B, HepG-2a, Huh7, LO2) |
| Expression Pattern | up-regulated |
| Function Description | LINC02476 expression was elevated in HCC cell lines and HCC tissues. When LINC02476 was downregulated, the growth and the invasion of HCC cells decreased in vitro and in vivo. LINC02476 negatively regulated the expression of miR-497 by acting as a ceRNA. HMGA2 was directly targeted and inhibited by miR-497. |
| Pubmed ID | 32280244 |
| Year | 2020 |
| Title | LINC02476 Promotes the Malignant Phenotype of Hepatocellular Carcinoma by Sponging miR-497 and Increasing HMGA2 Expression. |
External Links
| Links for LINC02476 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |