Basic Information
| LncRNA/CircRNA Name | LINC-ITGB1 |
| Synonyms | ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB |
| Region | GRCh38_10:32900319-33005792 |
| Ensemble | ENSG00000150093 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gallbladder cancer |
| ICD-0-3 | C23.9 |
| Methods | qPCR, Lentiviral infection, Western blot, MTT assay etc. |
| Sample | cell lines (GBC-SD and GBCSD/M) |
| Expression Pattern | up-regulated |
| Function Description | Functional analysis showed that knockdown of linc-ITGB1 significantly inhibited gallbladder cancer cell proliferation. Moreover, cell migration and invasion were reduced by over twofold in linc-ITGB1 knockdown cells probably due to upregulation of B-catenin and downregulation of vimentin, slug, and TCF8. |
| Pubmed ID | 25893892 |
| Year | 2015 |
| Title | Long non-coding RNA Linc-ITGB1 knockdown inhibits cell migration and invasion in GBC-SD/M and GBC-SD gallbladder cancer cell lines. |
External Links
| Links for LINC-ITGB1 | GenBank HGNC NONCODE |
| Links for gallbladder cancer | OMIM COSMIC |