Basic Information
| LncRNA/CircRNA Name | LINC-NeD125 |
| Synonyms | MIR100HG, AGD1, linc-NeD125, lncRNA-N2 |
| Region | GRCh38_11:122028327-122556721 |
| Ensemble | ENSG00000255248 |
| Refseq | NR_024430 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | neuroblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Cell transfection, Western blot, ChIP, RNA pull-down assay etc. |
| Sample | cell lines (BE(2)-C, D283 Med, NB4) |
| Expression Pattern | down-regulated |
| Function Description | Linc-NeD125 represents the host gene for miR-125b-1, a microRNA with an established role as negative regulator of human neuroblastoma cell proliferation. Here, we demonstrate that these two overlapping non coding RNAs are coordinately induced during in vitro neuronal differentiation, and that their expression is regulated by different mechanisms. While the production of miR-125b-1 relies on transcriptional regulation, linc-NeD125 is controlled at the post-transcriptional level, through modulation of its stability. |
| Pubmed ID | 26480000 |
| Year | 2015 |
| Title | Identification of linc-NeD125, a novel long non coding RNA that hosts miR-125b-1 and negatively controls proliferation of human neuroblastoma cells. |
External Links
| Links for LINC-NeD125 | GenBank HGNC NONCODE |
| Links for neuroblastoma | OMIM COSMIC |