Basic Information
| LncRNA/CircRNA Name | LINC-NeD125 |
| Synonyms | MIR100HG, AGD1, linc-NeD125, lncRNA-N2 |
| Region | GRCh38_11:122028327-122556721 |
| Ensemble | ENSG00000255248 |
| Refseq | NR_024430 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | medulloblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc. |
| Sample | medulloblastoma tissues, cell lines (BE(2)-C, D283 Med and CHLA-01 Med) |
| Expression Pattern | up-regulated |
| Function Description | Here we show that linc-NeD125, which we previously characterized as a neuronal-induced lncRNA, is significantly overexpressed in Group 4 medulloblastomas (G4 MBs), the largest and least well characterized molecular MB subgroup. Functionally, linc-NeD125 acts as a competing endogenous RNA (ceRNA) that, sequestering the three miRNAs, leads to de-repression of their targets CDK6, MYCN, SNCAIP, and KDM6A, which are major driver genes of G4 MB. |
| Pubmed ID | 28415684 |
| Year | 2017 |
| Title | The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity |
External Links
| Links for LINC-NeD125 | GenBank HGNC NONCODE |
| Links for medulloblastoma | OMIM COSMIC |