Basic Information
| LncRNA/CircRNA Name | LINC-OIP5 |
| Synonyms | OIP5-AS1, cyrano, linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000104147 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Western blotting |
| Sample | breast cancer cell lines (MDA-MB-231 and MCF-7) |
| Expression Pattern | up-regulated |
| Function Description | Linc-OIP5 is upregulated in MDA-MB-231 breast cancer cells. In addition, Linc-OIP5 knockdown inhibits MDA-MB-231 cell proliferation, migration and invasion, while inducing apoptosis, at least in part, through YAP1/JAG1 signaling. Linc-OIP5 may regulate JAG1 signaling through YAP1 signaling. |
| Pubmed ID | 31897120 |
| Year | 2020 |
| Title | Linc-OIP5 Loss Regulates Migration and Invasion in MDA-MB-231 Breast Cancer Cells by Inhibiting YAP1/JAG1 Signaling |
External Links
| Links for LINC-OIP5 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |