Basic Information
| LncRNA/CircRNA Name | LINC-OIP5 |
| Synonyms | OIP5-AS1, cyrano, linc-OIP5 |
| Region | GRCh38_15:41283990-41309737 |
| Ensemble | ENSG00000104147 |
| Refseq | NR_026757 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (T98G and A172) |
| Expression Pattern | up-regulated |
| Function Description | Level of linc-OIP5 was up-regulated in glioma tissues and significantly correlated with the advanced tumor stage (III/IV). Knockdown of linc-OIP5 can inhibit glioma cells proliferation, migration in vitro and tumor formation in vivo. Further mechanistic studies revealed the effect of linc-OIP5 knockdown on glioma cell phenotype at least partially through down-regulation of YAP and inhibition of Notch signaling pathway activity. |
| Pubmed ID | 28189759 |
| Year | 2017 |
| Title | Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway. |
External Links
| Links for LINC-OIP5 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |