Basic Information
| LncRNA/CircRNA Name | LINC-PINT |
| Synonyms | long intergenic non-protein-coding RNA p53-induced transcript |
| Region | GRCh38_7:130938963-131110176 |
| Ensemble | ENSG00000231721 |
| Refseq | NR_015431 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, RIP, Microarray |
| Sample | malignant melanoma cell line A375 and Mum2B,cell line CRMM1 and PIG1 |
| Expression Pattern | down-regulated |
| Function Description | LINC-PINT was significantly downregulated in melanoma tissues and cell lines. The overexpression of LINC-PINT in tumor cells resulted in significant tumor growth reduction and migration inhibition in A375, Mum2B and CRMM1 cells.LINC-PINT inhibits the tumorigenicity of melanoma through recruiting EZH2 to the promoter of its target genes, leading to H3K27 trimethylation and epigenetic silencing of target genes. |
| Pubmed ID | 31921860 |
| Year | 2020 |
| Title | Long Non-coding RNA LINC-PINT Suppresses Cell Proliferation and Migration of Melanoma via Recruiting EZH2 |
External Links
| Links for LINC-PINT | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |