Basic Information
| LncRNA/CircRNA Name | LINC-PINT |
| Synonyms | NA |
| Region | GRCh38_7:130938963-131110176 |
| Ensemble | ENSG00000231721 |
| Refseq | NR_015431 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR etc. |
| Sample | tumor tissues and adjacent healthy tissues ,human osteosarcoma cell lines(MG-63 and U2OS) |
| Expression Pattern | down-regulated |
| Function Description | LINC-PINT was inhibited, whereas miRNA-21 was promoted in tumor tissues than in adjacent healthy tissues of patients with osteosarcoma. Expression levels of LncRNA LINC-PINT were affected by both tumor size and tumor metastasis.LncRNA LINC-PINT overexpression led to downregulated miRNA-21 expression in cancer cells, whereas miRNA-21 overexpression did not significantly affect LINC-PINT expression.Overexpression of LncRNA LINC-PINT inhibited whereas miRNA-21 overexpression promoted cancer cell proliferation, migration, and invasion.In addition, miRNA-21 overexpression partially rescued the inhibited cell proliferation, migration, and invasion mediated by LncRNA LINC-PINT overexpression. |
| Pubmed ID | 31070482 |
| Year | 2019 |
| Title | LncRNA LINC-PINT Inhibits Cancer Cell Proliferation, Invasion, and Migration in Osteosarcoma by Downregulating miRNA-21 |
External Links
| Links for LINC-PINT | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |