Basic Information
| LncRNA/CircRNA Name | LINC-POU3F3 |
| Synonyms | POU3F3, BRN1, OTF8, brain-1, oct-8 |
| Region | GRCh38_2:104855511-104858574 |
| Ensemble | ENSG00000198914 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | doxycycline and diindolylmethane | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR |
| Sample | cell lines (HCT-116, HT-29) |
| Expression Pattern | differential expression |
| Function Description | RNA secretion into the bloodstream; we have shown for the first time that the treatment of HCT-116 and HT-29 colon cancer cells with two anti-cancer agents (doxycycline or 3, 3'-diindolylmethane) results in profound changes in the intracellular content of several lnc RNAs |
| Pubmed ID | 29116072 |
| Year | 2017 |
| Title | Treatment with anti-cancer agents results in profound changes in lncRNA expression in colon cancer cells |
External Links
| Links for LINC-POU3F3 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |