Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Western blot, Microarray |
| Sample | breast cancer tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | TAMs with lincRNA-p21 knockdown induced cancer cell apoptosis, inhibited tumor cell migration and invasion. In?vivo, lincRNA-p21 knockdown macrophage adoptive transfer could alleviate breast cancer progression. |
| Pubmed ID | 32062693 |
| Year | 2020 |
| Title | LincRNA-p21 knockdown reversed tumor-associated macrophages function by?promoting MDM2 to?antagonize* p53 activation and alleviate breast cancer development |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |