Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | RT-PCR, in vitro knockdown etc. |
| Sample | HepG2 liver cancer cell line |
| Expression Pattern | down-regulated |
| Function Description | Compared with that in the control group, the mRNA expression level of lincRNA-p21 in cells in the experimental group was obviously decreased. The proliferation ability of liver cancer cells was remarkably higher than that in the control group after knockout of lincRNA-p21.The invasion and migration ability of HepG2 cells in experimental group was markedly higher than that in control group. When lincRNA-p21 was inhibited, the proliferation, invasion and migration ability of HepG2 cells were significantly enhanced, and the apoptosis rate was significantly decreased. Thus, lincRNA-p21 on the surface may play an inhibitory role in the occurrence, development and metastasis of liver cancer. |
| Pubmed ID | 31186722 |
| Year | 2019 |
| Title | Effects of knockout of lincRNA-p21 on the proliferation, migration and invasion ability of HepG2 liver cancer cells |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |