Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot etc. |
| Sample | GC tissues, cell lines (MGC-803, MKN-45, BGC-823, MKN-28, SGC-7901, GES-1) |
| Expression Pattern | down-regulated |
| Function Description | p21 was significantly reduced in gastric cancer tissues (p<0.001) compared with that in normal tissues and this lower level of lincRNA-p21 was significantly correlated with higher invasion depth grade (p=0.024), more distant metastasis (p=0.009) and advanced TNM stage (p=0.011).The high incidence rate and relative low survival rate makes gastric cancer a significant threat to human health. |
| Pubmed ID | 28969031 |
| Year | 2017 |
| Title | Down regulation of lincRNA-p21 contributes to gastric cancer development through Hippo-independent activation of YAP. |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |