Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Northern blot, Luciferase reporter assay, Cell viability assay etc. |
| Sample | cell lines (SW480, SW620, HCT116, LoVo, HT29 and RKO) |
| Expression Pattern | down-regulated |
| Function Description | We measured the expression level of lincRNA-p21 and found that it was significantly downregulated in CRC specimens, as compared to the paired non-cancerous colorectal epithelia from 24 patients. mportantly, the expression levels of lincRNA-p21 were significantly lower in ALDH+ CSCs than ALDH- non-CSCs from several CRC cell lines as well as primary tumor cells CRC 1 |
| Pubmed ID | 26497997 |
| Year | 2015 |
| Title | miRNA-regulated delivery of lincRNA-p21 suppresses ?-catenin signaling and tumorigenicity of colorectal cancer stem cells |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |