Basic Information
| LncRNA/CircRNA Name | LINCRNA-p21 |
| Synonyms | TP53COR1, TRP53COR1, linc-p21, lincRNA-p21 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | CRC tissues, cell lines (SW1116, SW620, LS 174T, HT29, LOVO etc.) |
| Expression Pattern | down-regulated |
| Function Description | By expression profile analysis, we demonstrated that lincRNA-p21 decreases in CRC cell lines and tissue samples, which contributes to the elevation of B-catenin in CRC. We further showed that lincRNA-p21 increases following X-ray treatment, and enforced expression of the lincRNA enhances the sensitivity of radiotherapy for CRC by promoting cell apoptosis. |
| Pubmed ID | 24573322 |
| Year | 2014 |
| Title | LincRNA-p21 enhances the sensitivity of radiotherapy for human colorectal cancer by targeting the Wnt/B-Catenin signaling pathway. |
External Links
| Links for LINCRNA-p21 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |